ABSTRACT
Objective To evaluate the psychological distress of patients with retinal detachment and analyze its causes and related factors. Method We adopted a general information questionnaire and psychological distress thermometer (DT) to do a cross-sectional survey among patients undergoing retinal detachment reduction surgery between February 2016 and May 2017 in West China Hospital in Sichuan Province. Results The average score of psychological pain in the patients with retinal detachment was 4.3 ±2.0. Significant psychological distress was observed in 83 cases, which accounted for 67.5% (DT score was greater than 4). The top 5 factors for the psychological distress caused by the retinal detachment were edema, physical activity restricted, worry, bathing/dressing, and sleep problem. Multivariate linear regression analysis showed that age, sports, time of retinal detachment and combination of chronic diseases had an effect on psychological pain score (all P＜0.05). Conclusions The psychological distress of patients treated in retinal detachment reduction surgery is severe, and the physical problems are the main causes of psychological distress. In order to effectively prevent the emergence of psychological problems, psychological intervention measures should be taken in patients at young age, long time of retinal detachment, doing sports, and combination with other chronic diseases.
ABSTRACT
Objective To investigate effects of Ginkgo biloba extract(EGb) on expression of CREB and pCREB in cortex of aging rats.Methods Male Wistar rats were divided into three groups:young control group,old control group and EGb group.Rats in EGb group were treated with intragastric administration of EGb,while rats in the other two groups were treated with distilled water.The spatial learning and memory were evaluated by Morris water maze,and the expression of CREB,pCREB were detected by western blot.Results( 1 ) Compared with young control group (9.6 ± 2.88,41.55 ± 6.30),the swimming time and times through platform in the target quardrant of rats in old control group(6.8 ± 2.49,34.92 ± 4.56) were reduced (P ＜ 0.05 ).The times passing through the platform and the time exploring the target quadrant were more and longer in EGb group(9.4 ± 2.63,41.0 ± 6.68 ) than those in old control group(P ＜ 0.05 ).(2)Compared with rats in young control group( 1.07 ±0.33,0.26 ± 0.04),relative contents of CREB and p-CREB proteins in cortex (0.70 ± 0.21,0.13 ± 0.05 ) weredecreased in old control group(P＜0.05 ).CREB and p-CREB Levels were higher in EGb group ( 1.02 ±0.18,0.18 ±0.02)than those in old control group(P ＜ 0.05 ).Conclusion EGb can ameliorate spatial learning and memory of rats by increasing the expression of CREB and p-CREB in cortex.